Three inheritance patterns of HED are known: X-linked recessive, autosomal recessive, and autosomal dominant, corresponding to the main causative genes ( EDA, EDAR and EDARADD). The common clinical signs include dry skin, sparse hair, deformed teeth, diminished or absent of eccrine function and characteristic facial features including frontal bossing, chin prominence, saddle nose, maxillary hypoplasia, low-set ears, wrinkles, and periorbital hyperpigmentation. HED is characterized by hypohidrosis, hypotrichosis, hypodontia, and characteristic facial features. The most common type of ED, hypohidrotic ectodermal dysplasia (HED), occurs in 1 in 10,000–100,000 births (Chassaing, Bourthoumieu, Cossee, Calvas, & Vincent, 2006 Itin & Fistarol, 2004). Ectodermal dysplasia (ED) contains a group of more than 170 types of congenital disorders resulting from abnormal development of ectoderm-derived structures (Pinheiro & Freire-Maia, 1994 Priolo & Lagana, 2001).